Elafibranor modulates ileal macrophage polarization to restore intestinal integrity in NASH: Potential crosstalk between ileal IL-10/STAT3 and hepatic TLR4/NF-&#954;B axes.

Hakeem, Andrew N; Kamal, Mohamed M; Tawfiq, Rasha A; Abdelrahman, Basma A; Hammam, Olfat A; Elmazar, Mohamed M; El-Khatib, Aiman S; Attia, Yasmeen M

Elafibranor modulates ileal macrophage polarization to restore intestinal integrity in NASH: Potential crosstalk between ileal IL-10/STAT3 and hepatic TLR4/NF-κB axes.

Hakeem, Andrew N; Kamal, Mohamed M; Tawfiq, Rasha A; Abdelrahman, Basma A; Hammam, Olfat A; Elmazar, Mohamed M; El-Khatib, Aiman S; Attia, Yasmeen M.

Afiliação

Hakeem AN; Department of Pharmacology, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Kamal MM; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt
Tawfiq RA; Department of Pharmacology, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Abdelrahman BA; Department of Pharmacology, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Hammam OA; Department of Pathology, Theodor Bilharz Research Institute, Giza, Egypt.
Elmazar MM; Department of Pharmacology, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
El-Khatib AS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Attia YM; Department of Pharmacology, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt. Electronic address: yasmeen.attia@bue.edu.eg.

Biomed Pharmacother ; 157: 114050, 2023 Jan.

Article em En | MEDLINE | ID: mdl-36462310

Assuntos

Hepatopatia Gordurosa não Alcoólica; PPAR delta; Humanos; NF-kappa B/metabolismo; Interleucina-10/metabolismo; PPAR alfa/metabolismo; Hepatopatia Gordurosa não Alcoólica/metabolismo; Fígado/metabolismo; Macrófagos/metabolismo; PPAR delta/metabolismo; Receptor 4 Toll-Like/metabolismo; Fator de Transcrição STAT3/metabolismo

Palavras-chave

Intestinal permeability; Macrophage polarization; NASH; PPAR; STAT3; TLR4

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: PPAR delta / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google