New N-aryl-N-alkyl-thiophene-2-carboxamide compound enhances intracellular Ca<sup>2+</sup> dynamics by increasing SERCA2a Ca<sup>2+</sup> pumping.

Nikolaienko, Roman; Bovo, Elisa; Yuen, Samantha L; Treinen, Levy M; Berg, Kaja; Aldrich, Courtney C; Thomas, David D; Cornea, Razvan L; Zima, Aleksey V

New N-aryl-N-alkyl-thiophene-2-carboxamide compound enhances intracellular Ca²⁺ dynamics by increasing SERCA2a Ca²⁺ pumping.

Nikolaienko, Roman; Bovo, Elisa; Yuen, Samantha L; Treinen, Levy M; Berg, Kaja; Aldrich, Courtney C; Thomas, David D; Cornea, Razvan L; Zima, Aleksey V.

Afiliação

Nikolaienko R; Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
Bovo E; Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
Yuen SL; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Treinen LM; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Berg K; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota.
Aldrich CC; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota.
Thomas DD; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Cornea RL; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Zima AV; Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois. Electronic address: azima@luc.edu.

Biophys J ; 122(2): 386-396, 2023 01 17.

Article em En | MEDLINE | ID: mdl-36463408

Assuntos

Insuficiência Cardíaca; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático; Animais; Humanos; Camundongos; Cálcio/metabolismo; Insuficiência Cardíaca/metabolismo; Células HEK293; Miócitos Cardíacos/metabolismo; Retículo Sarcoplasmático/metabolismo; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/metabolismo; Tiofenos/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático / Insuficiência Cardíaca Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biophys J Ano de publicação: 2023 Tipo de documento: Article

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