Poricoic acid A suppresses renal fibroblast activation and interstitial fibrosis in UUO rats via upregulating Sirt3 and promoting ß-catenin K49 deacetylation.

Chen, Dan-Qian; Chen, Lin; Guo, Yan; Wu, Xia-Qing; Zhao, Ting-Ting; Zhao, Hai-Ling; Zhang, Hao-Jun; Yan, Mei-Hua; Zhang, Guo-Qiang; Li, Ping

Chen, Dan-Qian; Chen, Lin; Guo, Yan; Wu, Xia-Qing; Zhao, Ting-Ting; Zhao, Hai-Ling; Zhang, Hao-Jun; Yan, Mei-Hua; Zhang, Guo-Qiang; Li, Ping.

Afiliação

Chen DQ; Department of Emergency, China-Japan Friendship Hospital, Beijing, 100029, China. chendanqian2013@163.com.
Chen L; Faculty of Life Science & Medicine, Northwest University, Xi'an, 710069, China.
Guo Y; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
Wu XQ; Faculty of Life Science & Medicine, Northwest University, Xi'an, 710069, China.
Zhao TT; Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China.
Zhao HL; Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China.
Zhang HJ; Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China.
Yan MH; Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China.
Zhang GQ; Department of Emergency, China-Japan Friendship Hospital, Beijing, 100029, China.
Li P; Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China. lp8675@163.com.

Acta Pharmacol Sin ; 44(5): 1038-1050, 2023 May.

Article em En | MEDLINE | ID: mdl-36470978

Assuntos

Nefropatias; Sirtuína 3; Triterpenos; beta Catenina; Animais; Camundongos; Ratos; beta Catenina/química; beta Catenina/metabolismo; Fibroblastos; Fibrose/tratamento farmacológico; Fibrose/patologia; Rim/patologia; Nefropatias/tratamento farmacológico; Nefropatias/patologia; Simulação de Acoplamento Molecular; Transdução de Sinais; Sirtuína 3/efeitos dos fármacos; Sirtuína 3/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Obstrução Ureteral/complicações; Obstrução Ureteral/tratamento farmacológico; Obstrução Ureteral/metabolismo; Triterpenos/farmacologia; Triterpenos/uso terapêutico

Palavras-chave

deacetylation; fibroblast activation; poricoic acid A; renal interstitial fibrosis; sirt3; unilateral ureteral obstruction (UUO); ß-catenin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Beta Catenina / Sirtuína 3 / Nefropatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Pharmacol Sin Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google