Lanostane triterpenoids from the fungus Physisporinus vitreus and their inhibitory activity against nitric oxide production.
Phytochemistry
; 206: 113556, 2023 Feb.
Article
em En
| MEDLINE
| ID: mdl-36496004
ABSTRACT
Eight undescribed lanostane triterpenoids, physivitrins A-H, along with four known analogues, were isolated from cultures of the fungus Physisporinus vitreus. Their structures were elucidated on the basis of extensive spectroscopic methods, in which the absolute configuration of physivitrin A was elucidated using electronic circular dichroism calculation and nuclear magnetic resonance (NMR) calculation with DP4+ analysis. Physivitrins B and C showed inhibitory activities against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages with IC50 values of 7.5 and 23.5 µM, respectively. Meanwhile, proinflammatory cytokines (TNF-α, iNOS and IL-1ß) mRNA expression was also inhibited by physivitrin B significantly.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Polyporales
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2023
Tipo de documento:
Article