An implantable soft robotic ventilator augments inspiration in a pig model of respiratory insufficiency.
Nat Biomed Eng
; 7(2): 110-123, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-36509912
ABSTRACT
Severe diaphragm dysfunction can lead to respiratory failure and to the need for permanent mechanical ventilation. Yet permanent tethering to a mechanical ventilator through the mouth or via tracheostomy can hinder a patient's speech, swallowing ability and mobility. Here we show, in a porcine model of varied respiratory insufficiency, that a contractile soft robotic actuator implanted above the diaphragm augments its motion during inspiration. Synchronized actuation of the diaphragm-assist implant with the native respiratory effort increased tidal volumes and maintained ventilation flow rates within the normal range. Robotic implants that intervene at the diaphragm rather than at the upper airway and that augment physiological metrics of ventilation may restore respiratory performance without sacrificing quality of life.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Respiratória
/
Robótica
Aspecto:
Patient_preference
Limite:
Animals
Idioma:
En
Revista:
Nat Biomed Eng
Ano de publicação:
2023
Tipo de documento:
Article