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Dysfunctional Extracellular Matrix Remodeling Supports Perianal Fistulizing Crohn's Disease by a Mechanoregulated Activation of the Epithelial-to-Mesenchymal Transition.
Rizzo, Giulia; Rubbino, Federica; Elangovan, Sudharshan; Sammarco, Giusy; Lovisa, Sara; Restelli, Silvia; Pineda Chavez, Samuel Elias; Massimino, Luca; Lamparelli, Luigi; Paulis, Marianna; Maroli, Annalisa; Roda, Giulia; Shalaby, Mohammad; Carvello, Michele; Foppa, Caterina; Drummond, Sheona P; Spaggiari, Paola; Ungaro, Federica; Spinelli, Antonino; Malesci, Alberto; Repici, Alessandro; Day, Anthony J; Armuzzi, Alessandro; Danese, Silvio; Vetrano, Stefania.
Afiliação
  • Rizzo G; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
  • Rubbino F; Laboratory of Molecular Gastroenterology, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Elangovan S; Genomics Division, Wipro Life Sciences Lab, Wipro Limited, Bengaluru, India.
  • Sammarco G; IBD Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Lovisa S; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; IBD Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Restelli S; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
  • Pineda Chavez SE; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
  • Massimino L; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milan, Italy; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Lamparelli L; IBD Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Paulis M; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Institute of Genetic and Biomedical Research, UOS Milan, National Research Council of Italy, Milan, Italy.
  • Maroli A; Colon and Rectal Surgery Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Roda G; IBD Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Shalaby M; IBD Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Carvello M; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; Colon and Rectal Surgery Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Foppa C; Colon and Rectal Surgery Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Drummond SP; Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.
  • Spaggiari P; Department of Pathology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Ungaro F; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milan, Italy; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milan, Italy; Faculty of Medicine, Università Vita-Salute San Raffaele, Milan, Italy.
  • Spinelli A; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; Colon and Rectal Surgery Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Malesci A; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milan, Italy; Faculty of Medicine, Università Vita-Salute San Raffaele, Milan, Italy.
  • Repici A; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; Digestive Endoscopy Unit, Department of Gastroenterology, IRCCS Humanitas Clinical and Research Center, Rozzano, Italy.
  • Day AJ; Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine, and Health, Manchester Academic Hea
  • Armuzzi A; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; IBD Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Danese S; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milan, Italy; Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milan, Italy; Faculty of Medicine, Università Vita-Salute San Raffaele, Milan, Italy.
  • Vetrano S; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; IBD Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy. Electronic address: stefania.vetrano@hunimed.eu.
Cell Mol Gastroenterol Hepatol ; 15(3): 741-764, 2023.
Article em En | MEDLINE | ID: mdl-36521659
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Crohn / Fístula Retal Limite: Humans Idioma: En Revista: Cell Mol Gastroenterol Hepatol Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Crohn / Fístula Retal Limite: Humans Idioma: En Revista: Cell Mol Gastroenterol Hepatol Ano de publicação: 2023 Tipo de documento: Article