Transient receptor potential ion channels and cerebral stroke.
Brain Behav
; 13(1): e2843, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36527242
ABSTRACT
METHODS:
The databases Pubmed, and the National Library of Medicine were searched for literature. All papers on celebral stroke and transient receptor potential ion channels were considered.RESULTS:
Stroke is the second leading cause of death and disability, with an increasing incidence in developing countries. About 75 per cent of strokes are caused by occlusion of cerebral arteries, and substantial advances have been made in elucidating mechanisms how stroke affects the brain. Transient receptor potential (TRP) ion channels are calcium-permeable channels highly expressed in brain that drives Ca2+ entry into multiple cellular compartments. TRPC1/3/4/6, TRPV1/2/4, and TRPM2/4/7 channels have been implicated in stroke pathophysiology.CONCLUSIONS:
Although the precise mechanism of transient receptor potential ion channels in cerebral stroke is still unclear, it has the potential to be a therapeutic target for patients with stroke if developed appropriately. Hence, more research is needed to prove its efficacy in this context.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acidente Vascular Cerebral
/
Canais de Potencial de Receptor Transitório
/
Canais de Cátion TRPM
Limite:
Humans
Idioma:
En
Revista:
Brain Behav
Ano de publicação:
2023
Tipo de documento:
Article