Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action.

Lai, Jing Wei; Maah, Mohd Jamil; Tan, Kong Wai; Sarip, Rozie; Lim, Yvonne Ai Lian; Ganguly, Rakesh; Khaw, Loke Tim; Ng, Chew Hee

Lai, Jing Wei; Maah, Mohd Jamil; Tan, Kong Wai; Sarip, Rozie; Lim, Yvonne Ai Lian; Ganguly, Rakesh; Khaw, Loke Tim; Ng, Chew Hee.

Afiliação

Lai JW; Department of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Maah MJ; Department of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Tan KW; Department of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Sarip R; Department of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Lim YAL; Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Ganguly R; Shiv Nadar University, Greater Noida, India.
Khaw LT; Department of Microbiology and Immunology, School of Medicine, International Medical University, 57000, Kuala Lumpur, Malaysia.
Ng CH; Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 57000, Kuala Lumpur, Malaysia. NgChewHee@imu.edu.my.

Malar J ; 21(1): 386, 2022 Dec 17.

Article em En | MEDLINE | ID: mdl-36528584

Assuntos

Antimaláricos; Artemisininas; Complexos de Coordenação; Malária Falciparum; Malária; Humanos; Plasmodium falciparum; Antimaláricos/uso terapêutico; Complexos de Coordenação/química; Complexos de Coordenação/farmacologia; Complexos de Coordenação/uso terapêutico; Cobre/farmacologia; Cobre/uso terapêutico; Artemisininas/uso terapêutico; Resistência a Medicamentos; Malária/tratamento farmacológico; Metais; Zinco/farmacologia; Zinco/uso terapêutico; Malária Falciparum/tratamento farmacológico

Palavras-chave

Antimalarial; Apoptosis; Copper complex; Depolarization of mitochondrial membrane potential; Plasmodium falciparum; Proteasome inhibition; Reactive oxygen species; Zinc complex

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND / 4_TD Base de dados: MEDLINE Assunto principal: Malária Falciparum / Artemisininas / Complexos de Coordenação / Malária / Antimaláricos Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Malar J Ano de publicação: 2022 Tipo de documento: Article

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