Evolutionary trade-offs associated with copy number variations in resistance alleles in Culex pipiens mosquitoes.
Parasit Vectors
; 15(1): 484, 2022 Dec 22.
Article
em En
| MEDLINE
| ID: mdl-36550589
ABSTRACT
Organophosphate and carbamate insecticides have largely been used worldwide to control mosquito populations. As a response, the same amino acid substitution in the ace-1 gene (G119S), conferring resistance to both insecticides, has been selected independently in many mosquito species. In Anopheles gambiae, it has recently been shown that the G119S mutation is actually part of homogeneous duplications that associate multiple resistance copies of the ace-1 gene. In this study, we showed that duplications of resistance copies of the ace-1 gene also exist in the Culex pipiens species complex. The number of copies is variable, and different numbers of copies are associated with different phenotypic trade-offs we used a combination of bioassays and competition in population cages to show that having more resistance copies conferred higher resistance levels, but was also associated with higher selective disadvantage (or cost) in the absence of insecticide. These results further show the versatility of the genetic architecture of resistance to organophosphate and carbamate insecticides around the ace-1 locus and its role in fine-tuned adaptation to insecticide treatment variations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Culex
/
Inseticidas
/
Anopheles
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Parasit Vectors
Ano de publicação:
2022
Tipo de documento:
Article