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Undifferentiated Pancreatic Carcinomas, Clinical Features and Therapeutic Options: What We Know.
Mugaanyi, Joseph; Lu, Changjiang; Huang, Jing; Lu, Caide.
Afiliação
  • Mugaanyi J; School of Medicine, Ningbo University, Ningbo 315211, China.
  • Lu C; Department of Hepato-Pancreato-Billiary Surgery, Ningbo Medical Center Li Huili Hospital, Ningbo University, Ningbo 315211, China.
  • Huang J; Department of Hepato-Pancreato-Billiary Surgery, Ningbo Medical Center Li Huili Hospital, Ningbo University, Ningbo 315211, China.
  • Lu C; Department of Hepato-Pancreato-Billiary Surgery, Ningbo Medical Center Li Huili Hospital, Ningbo University, Ningbo 315211, China.
Cancers (Basel) ; 14(24)2022 Dec 12.
Article em En | MEDLINE | ID: mdl-36551588
ABSTRACT
Undifferentiated pancreatic carcinomas are rare malignant tumors of the pancreas that are very aggressive and challenging to diagnose. The WHO categorizes them into undifferentiated osteoclast-like giant cell, sarcomatoid, and rhabdoid pancreatic carcinomas. Patients present with nonspecific symptoms such as jaundice, vague abdominal or back pain and itchy skin. Their histological characteristics include positive pan-cytokeratin mononuclear pleomorphic cells, osteoclast-like giant cells and CD68. Patients may have KRAS, TP53 and SMAD4 alterations, homozygous deletions of CDKN2A and CDKN2B, as well as INI1 deficiency. Surgical resection is the only curative treatment. Patients may benefit from postoperative adjuvant therapy. There are no widely accepted guidelines specific to this type of tumor; however, some chemotherapy regimens may be promising. The patient prognosis is mostly poor, especially in patients with unresectable tumors. However, several studies have shown patients achieving long-term survival with adjuvant therapy. In conclusion, although undifferentiated pancreatic carcinoma is rare and very aggressive, there is still potential for improved patient survival with proper diagnosis and treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: Cancers (Basel) Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: Cancers (Basel) Ano de publicação: 2022 Tipo de documento: Article