PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux.

Ben-Zvi, Hadas; Rabinski, Tatiana; Ofir, Rivka; Cohen, Smadar; Vatine, Gad D

Ben-Zvi, Hadas; Rabinski, Tatiana; Ofir, Rivka; Cohen, Smadar; Vatine, Gad D.

Afiliação

Ben-Zvi H; The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
Rabinski T; The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
Ofir R; The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
Cohen S; Dead Sea & Arava Science Center, Masada 8691000, Israel.
Vatine GD; The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.

Int J Mol Sci ; 23(24)2022 Dec 17.

Article em En | MEDLINE | ID: mdl-36555735

Assuntos

Células-Tronco Pluripotentes Induzidas; Humanos; Autofagia/genética; Autofagossomos/metabolismo; Lisossomos/metabolismo; Neurônios Motores

Palavras-chave

DCM-LVNC; PLEKHM2; autophagosomes; autophagy; disease model; iPSCs; lysosomes; motor neurons; neurodegeneration; neurons

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article

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