Mesothelioma cancer cells are glutamine addicted and glutamine restriction reduces YAP1 signaling to attenuate tumor formation.

Adhikary, Gautam; Shrestha, Suruchi; Naselsky, Warren; Newland, John J; Chen, Xi; Xu, Wen; Emadi, Ashkan; Friedberg, Joseph S; Eckert, Richard L

Adhikary, Gautam; Shrestha, Suruchi; Naselsky, Warren; Newland, John J; Chen, Xi; Xu, Wen; Emadi, Ashkan; Friedberg, Joseph S; Eckert, Richard L.

Afiliação

Adhikary G; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shrestha S; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Naselsky W; Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Newland JJ; Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Chen X; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Xu W; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Emadi A; Department of Medicine, University of Maryland School of Medicine.
Friedberg JS; The Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Eckert RL; Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

Mol Carcinog ; 62(4): 438-449, 2023 04.

Article em En | MEDLINE | ID: mdl-36562471

Assuntos

Mesotelioma Maligno; Mesotelioma; Humanos; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo; Glutamina/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/genética; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Proteínas de Sinalização YAP; Mesotelioma/genética; Proliferação de Células; Linhagem Celular Tumoral; Antígenos de Histocompatibilidade Menor/genética; Sistema ASC de Transporte de Aminoácidos/genética; Sistema ASC de Transporte de Aminoácidos/metabolismo

Palavras-chave

GLS; SLC1A5; glutamine addiction; glutamine depletion therapy; mesothelioma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mesotelioma Maligno / Mesotelioma Limite: Humans Idioma: En Revista: Mol Carcinog Ano de publicação: 2023 Tipo de documento: Article

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