Catalyst Controlled Site- and Stereoselective Rhodium(II) Carbene C(sp3)-H Functionalization of Allyl Boronates.
Org Lett
; 25(1): 5-10, 2023 01 13.
Article
em En
| MEDLINE
| ID: mdl-36563330
ABSTRACT
Rhodium(II) catalyst-controlled site- and stereoselective carbene insertion into the distal allylic C(sp3)-H bond of allyl boronates is reported. The optimum chiral catalyst for this reaction is Rh2(S-TPPTTL)4. The fidelity and asymmetric induction of this catalytic transformation allows for a highly diastereoselective and enantioselective C-C bond formation without interference from the allyl boronate functionality. The resulting functionalized allyl boronates are susceptible to stereoselective allylations, generating products with control of stereochemistry at four contiguous stereogenic centers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ródio
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2023
Tipo de documento:
Article