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A molecular barcode and web-based data analysis tool to identify imported Plasmodium vivax malaria.
Trimarsanto, Hidayat; Amato, Roberto; Pearson, Richard D; Sutanto, Edwin; Noviyanti, Rintis; Trianty, Leily; Marfurt, Jutta; Pava, Zuleima; Echeverry, Diego F; Lopera-Mesa, Tatiana M; Montenegro, Lidia M; Tobón-Castaño, Alberto; Grigg, Matthew J; Barber, Bridget; William, Timothy; Anstey, Nicholas M; Getachew, Sisay; Petros, Beyene; Aseffa, Abraham; Assefa, Ashenafi; Rahim, Awab G; Chau, Nguyen H; Hien, Tran T; Alam, Mohammad S; Khan, Wasif A; Ley, Benedikt; Thriemer, Kamala; Wangchuck, Sonam; Hamedi, Yaghoob; Adam, Ishag; Liu, Yaobao; Gao, Qi; Sriprawat, Kanlaya; Ferreira, Marcelo U; Laman, Moses; Barry, Alyssa; Mueller, Ivo; Lacerda, Marcus V G; Llanos-Cuentas, Alejandro; Krudsood, Srivicha; Lon, Chanthap; Mohammed, Rezika; Yilma, Daniel; Pereira, Dhelio B; Espino, Fe E J; Chu, Cindy S; Vélez, Iván D; Namaik-Larp, Chayadol; Villegas, Maria F; Green, Justin A.
Afiliação
  • Trimarsanto H; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
  • Amato R; Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
  • Pearson RD; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
  • Sutanto E; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
  • Noviyanti R; Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
  • Trianty L; Exeins Health Initiative, Jakarta, Indonesia.
  • Marfurt J; Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
  • Pava Z; Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
  • Echeverry DF; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
  • Lopera-Mesa TM; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
  • Montenegro LM; International Training and Medical Research Center (CIDEIM), Cali, Colombia.
  • Tobón-Castaño A; Departamento de Microbiología, Universidad del Valle, Cali, Colombia.
  • Grigg MJ; Universidad Icesi, Cali, Colombia.
  • Barber B; Malaria Group, Universidad de Antioquia, Medellin, Colombia.
  • William T; Malaria Group, Universidad de Antioquia, Medellin, Colombia.
  • Anstey NM; Malaria Group, Universidad de Antioquia, Medellin, Colombia.
  • Getachew S; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
  • Petros B; Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia.
  • Aseffa A; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
  • Assefa A; Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia.
  • Rahim AG; Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia.
  • Chau NH; Clinical Research Centre, Queen Elizabeth Hospital, Sabah, Malaysia.
  • Hien TT; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
  • Alam MS; College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
  • Khan WA; Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
  • Ley B; College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
  • Thriemer K; Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
  • Wangchuck S; Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
  • Hamedi Y; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
  • Adam I; Nangarhar Medical Faculty, Nangarhar University, Ministry of Higher Education, Jalalabad, Afghanistan.
  • Liu Y; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
  • Gao Q; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
  • Sriprawat K; Infectious Diseases Division, International Centre for Diarrheal Diseases Research, Dhaka, Bangladesh.
  • Ferreira MU; Infectious Diseases Division, International Centre for Diarrheal Diseases Research, Dhaka, Bangladesh.
  • Laman M; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
  • Barry A; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
  • Mueller I; Royal Center for Disease Control, Department of Public Health, Ministry of Health, Thimphu, Bhutan.
  • Lacerda MVG; Infectious and Tropical Diseases Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Hormozgan Province, Iran.
  • Llanos-Cuentas A; Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
  • Krudsood S; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
  • Lon C; School of Public Health, Nanjing Medical University, Nanjing, China.
  • Mohammed R; National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
  • Yilma D; Shoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
  • Pereira DB; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Espino FEJ; Global Health and Tropical Medicine, Institute of Hygiene and Tropical Medicine, NOVA University of Lisbon, Lisbon, Portugal.
  • Chu CS; Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
  • Vélez ID; Deakin University, Victoria, Australia.
  • Namaik-Larp C; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
  • Villegas MF; Department of Medical Biology, The University of Melbourne, Victoria, Australia.
  • Green JA; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
Commun Biol ; 5(1): 1411, 2022 12 23.
Article em En | MEDLINE | ID: mdl-36564617
Traditionally, patient travel history has been used to distinguish imported from autochthonous malaria cases, but the dormant liver stages of Plasmodium vivax confound this approach. Molecular tools offer an alternative method to identify, and map imported cases. Using machine learning approaches incorporating hierarchical fixation index and decision tree analyses applied to 799 P. vivax genomes from 21 countries, we identified 33-SNP, 50-SNP and 55-SNP barcodes (GEO33, GEO50 and GEO55), with high capacity to predict the infection's country of origin. The Matthews correlation coefficient (MCC) for an existing, commonly applied 38-SNP barcode (BR38) exceeded 0.80 in 62% countries. The GEO panels outperformed BR38, with median MCCs > 0.80 in 90% countries at GEO33, and 95% at GEO50 and GEO55. An online, open-access, likelihood-based classifier framework was established to support data analysis (vivaxGEN-geo). The SNP selection and classifier methods can be readily amended for other use cases to support malaria control programs.
Assuntos

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Malária Vivax / Malária Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Commun Biol Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Malária Vivax / Malária Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Commun Biol Ano de publicação: 2022 Tipo de documento: Article