Incorporation of a recirculating mobile lipid pool description into the cyclic volatile siloxane (cVMS) PBPK model captures terminal clearance of D<sub>4</sub> after repeated inhalation exposure in F344 and SD Rats.

Campbell, Jerry; Andersen, Melvin; Gentry, Robinan; Landingham, Cynthia Van; Clewell, Harvey

Incorporation of a recirculating mobile lipid pool description into the cyclic volatile siloxane (cVMS) PBPK model captures terminal clearance of D₄ after repeated inhalation exposure in F344 and SD Rats.

Campbell, Jerry; Andersen, Melvin; Gentry, Robinan; Landingham, Cynthia Van; Clewell, Harvey.

Afiliação

Campbell J; Ramboll US Consulting, Inc., 3214 Charles B. Root Wynd, Suite 130, Raleigh, NC 27612, USA. Electronic address: jcampbell@ramboll.com.
Andersen M; Andersen ToxConsulting LLC, Denver, NC 28037, USA.
Gentry R; Ramboll US Consulting, Inc., 3107 Armand Street, Monroe, LA 71201, USA.
Landingham CV; Ramboll US Consulting, Inc., 3107 Armand Street, Monroe, LA 71201, USA.
Clewell H; Ramboll US Consulting, Inc., 3214 Charles B. Root Wynd, Suite 130, Raleigh, NC 27612, USA.

Toxicol Lett ; 375: 29-38, 2023 Feb 15.

Article em En | MEDLINE | ID: mdl-36596351

Assuntos

Exposição por Inalação; Siloxanas; Ratos; Masculino; Feminino; Humanos; Animais; Ratos Endogâmicos F344; Exposição por Inalação/efeitos adversos; Siloxanas/toxicidade; Siloxanas/farmacocinética; Cinética; Ratos Sprague-Dawley; Modelos Biológicos; Lipídeos

Palavras-chave

Cyclic siloxane; Hepatic induction; Mobile lipid pool; Octamethylcyclotetrasiloxane (D4); Physiologically based pharmacokinetic model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Siloxanas / Exposição por Inalação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Toxicol Lett Ano de publicação: 2023 Tipo de documento: Article

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