Global Analysis of <i>Plasmodium falciparum</i> Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study.

Boateng, Rita Afriyie; Myers-Hansen, James L; Dolling, Nigel N O; Mensah, Benedicta A; Brodsky, Elia; Mazumder, Mohit; Ghansah, Anita

Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study.

Boateng, Rita Afriyie; Myers-Hansen, James L; Dolling, Nigel N O; Mensah, Benedicta A; Brodsky, Elia; Mazumder, Mohit; Ghansah, Anita.

Afiliação

Boateng RA; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Myers-Hansen JL; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Dolling NNO; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Mensah BA; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Brodsky E; Pine Biotech, Inc., 1441 Canal St., New Orleans, LA 70112, USA.
Mazumder M; Pine Biotech, Inc., 1441 Canal St., New Orleans, LA 70112, USA.
Ghansah A; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.

Molecules ; 28(1)2022 Dec 24.

Article em En | MEDLINE | ID: mdl-36615340

Assuntos

Antimaláricos; Di-Hidropteroato Sintase; Malária Falciparum; Plasmodium falciparum; Criança; Feminino; Humanos; Gravidez; Antimaláricos/farmacologia; Antimaláricos/uso terapêutico; Di-Hidropteroato Sintase/genética; Combinação de Medicamentos; Resistência a Medicamentos/genética; Malária Falciparum/tratamento farmacológico; Malária Falciparum/genética; Simulação de Acoplamento Molecular; Mutação; Sulfadoxina/farmacologia; Sulfadoxina/uso terapêutico; Tetra-Hidrofolato Desidrogenase/genética

Palavras-chave

Pfdhps; haplotype; malaria; molecular docking; molecular dynamics simulations; mutations; sulfadoxine resistance

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Malária Falciparum / Di-Hidropteroato Sintase / Antimaláricos Tipo de estudo: Risk_factors_studies Limite: Child / Female / Humans / Pregnancy Idioma: En Revista: Molecules Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google