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Defining left ventricular remodeling using lean body mass allometry: a UK Biobank study.
Gomes, Bruna; Hedman, Kristofer; Kuznetsova, Tatiana; Cauwenberghs, Nicholas; Hsu, David; Kobayashi, Yukari; Ingelsson, Erik; Oxborough, David; George, Keith; Salerno, Michael; Ashley, Euan; Haddad, Francois.
Afiliação
  • Gomes B; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94304, USA. bgomes@stanford.edu.
  • Hedman K; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. bgomes@stanford.edu.
  • Kuznetsova T; Department of Cardiology, Pneumology and Angiology, Heidelberg University Hospital, Heidelberg, Germany. bgomes@stanford.edu.
  • Cauwenberghs N; Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94304, USA. bgomes@stanford.edu.
  • Hsu D; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94304, USA.
  • Kobayashi Y; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
  • Ingelsson E; Department of Clinical Physiology in Linköping, Linköping University, Linköping, Sweden.
  • Oxborough D; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
  • George K; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
  • Salerno M; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
  • Ashley E; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94304, USA.
  • Haddad F; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94304, USA.
Eur J Appl Physiol ; 123(5): 989-1001, 2023 May.
Article em En | MEDLINE | ID: mdl-36617359
ABSTRACT

PURPOSE:

The geometric patterns of ventricular remodeling are determined using indexed left ventricular mass (LVM), end-diastolic volume (LVEDV) and concentricity, most often measured using the mass-to-volume ratio (MVR). The aims of this study were to validate lean body mass (LBM)-based allometric coefficients for scaling and to determine an index of concentricity that is independent of both volume and LBM.

METHODS:

Participants from the UK Biobank who underwent both CMR and dual-energy X-ray absorptiometry (DXA) during 2014-2015 were considered (n = 5064). We excluded participants aged ≥ 70 years or those with cardiometabolic risk factors. We determined allometric coefficients for scaling using linear regression of the logarithmically transformed ventricular remodeling parameters. We further defined a multiplicative allometric relationship for LV concentricity (LVC) adjusting for both LVEDV and LBM.

RESULTS:

A total of 1638 individuals (1057 female) were included. In subjects with lower body fat percentage (< 25% in males, < 35% in females, n = 644), the LBM allometric coefficients for scaling LVM and LVEDV were 0.85 ± 0.06 and 0.85 ± 0.03 respectively (R2 = 0.61 and 0.57, P < 0.001), with no evidence of sex-allometry interaction. While the MVR was independent of LBM, it demonstrated a negative association with LVEDV in (females r = - 0.44, P < 0.001; males - 0.38, P < 0.001). In contrast, LVC was independent of both LVEDV and LBM [LVC = LVM/(LVEDV0.40 × LBM0.50)] leading to increased overlap between LV hypertrophy and higher concentricity.

CONCLUSIONS:

We validated allometric coefficients for LBM-based scaling for CMR indexed parameters relevant for classifying geometric patterns of ventricular remodeling.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bancos de Espécimes Biológicos / Remodelação Ventricular Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Eur J Appl Physiol Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bancos de Espécimes Biológicos / Remodelação Ventricular Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Eur J Appl Physiol Ano de publicação: 2023 Tipo de documento: Article