Synthesis and characterization of two piperazine containing macrocycles and their transition metal complexes.
J Inorg Biochem
; 241: 112124, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36652846
ABSTRACT
Rigidification of the ligand scaffolds has been a particular mechanism of interest employed to achieve properties suitable for MRI contrast, catalysis, or other applications of metal complexes. Towards the goal of targeting a 15-anePyN5Pip type ligand, a serendipitous isolation of a 30-anePy2N10Pip2 aza-macrocycle was achieved, instead. X-ray diffraction and determination of pKa events were carried out and compared to 17-anePyN5Pip. Furthermore, the X-ray diffraction of the Cu(II) and Zn(II) complexes of 17-anePyN5Pip was achieved and compared to previous reports of other first-row transition metal derivatives of this ligand. Determination of the log ß with both 30-anePy2N10Pip2 and 17-anePyN5Pip with the divalent MnZn metal-ion series was used to demonstrate the impact that the piperazine ring plays compared to other, less rigid macrocycles reported to date.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Elementos de Transição
/
Complexos de Coordenação
Idioma:
En
Revista:
J Inorg Biochem
Ano de publicação:
2023
Tipo de documento:
Article