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Evaluation of the Efficiency of Random and Diblock Methacrylate-Based Amphiphilic Cationic Polymers against Major Bacterial Pathogens Associated with Cystic Fibrosis.
Casanova, Magali; Olleik, Hamza; Hdiouech, Slim; Roblin, Clarisse; Cavalier, Jean-François; Point, Vanessa; Jeannot, Katy; Caron, Baptiste; Perrier, Josette; Charriau, Siméon; Lafond, Mickael; Guillaneuf, Yohann; Canaan, Stéphane; Lefay, Catherine; Maresca, Marc.
Afiliação
  • Casanova M; CNRS, Aix-Marseille Univ, LISM UMR7255, IMM FR3479, 13402 Marseille, France.
  • Olleik H; Aix Marseille Univ, CNRS, Centrale Marseille, iSm2 (UMR7313), 13013 Marseille, France.
  • Hdiouech S; Aix Marseille Univ, CNRS, ICR, UMR7273, 13397 Marseille, France.
  • Roblin C; Aix Marseille Univ, CNRS, Centrale Marseille, iSm2 (UMR7313), 13013 Marseille, France.
  • Cavalier JF; CNRS, Aix-Marseille Univ, LISM UMR7255, IMM FR3479, 13402 Marseille, France.
  • Point V; CNRS, Aix-Marseille Univ, LISM UMR7255, IMM FR3479, 13402 Marseille, France.
  • Jeannot K; Laboratoire Associé au CNR de la Résistance aux Antibiotiques, Centre Hospitalier Universitaire de Besançon, Boulevard Fleming, 25000 Besançon, France.
  • Caron B; Aix Marseille Univ, CNRS, ICR, UMR7273, 13397 Marseille, France.
  • Perrier J; Aix Marseille Univ, CNRS, Centrale Marseille, iSm2 (UMR7313), 13013 Marseille, France.
  • Charriau S; Aix Marseille Univ, CNRS, Centrale Marseille, iSm2 (UMR7313), 13013 Marseille, France.
  • Lafond M; Aix Marseille Univ, CNRS, Centrale Marseille, iSm2 (UMR7313), 13013 Marseille, France.
  • Guillaneuf Y; Aix Marseille Univ, CNRS, ICR, UMR7273, 13397 Marseille, France.
  • Canaan S; CNRS, Aix-Marseille Univ, LISM UMR7255, IMM FR3479, 13402 Marseille, France.
  • Lefay C; Aix Marseille Univ, CNRS, ICR, UMR7273, 13397 Marseille, France.
  • Maresca M; Aix Marseille Univ, CNRS, Centrale Marseille, iSm2 (UMR7313), 13013 Marseille, France.
Antibiotics (Basel) ; 12(1)2023 Jan 08.
Article em En | MEDLINE | ID: mdl-36671321
Cystic fibrosis (CF) is associated with repeated lung bacterial infection, mainly by Pseudomonas aeruginosa, Staphylococcus aureus, and Mycobacterium abscessus, all known to be or becoming resistant to several antibiotics, often leading to therapeutic failure and death. In this context, antimicrobial peptides and antimicrobial polymers active against resistant strains and less prompt to cause resistance, appear as a good alternative to conventional antibiotics. In the present study, methacrylate-based copolymers obtained by radical chemistry were evaluated against CF-associated bacterial strains. Results showed that the type (Random versus Diblock) and the size of the copolymers affected their antibacterial activity and toxicity. Among the different copolymers tested, four (i.e., Random10200, Random15000, Random23900, and Diblock9500) were identified as the most active and the safest molecules and were further investigated. Data showed that they inserted into bacterial lipids, leading to a rapid membranolytic effect and killing of the bacterial. In relation with their fast bactericidal action and conversely to conventional antibiotics, those copolymers did not induce a resistance and remained active against antibiotic-resistant strains. Finally, the selected copolymers possessed a preventive effect on biofilm formation, although not exhibiting disruptive activity. Overall, the present study demonstrates that methacrylate-based copolymers are an interesting alternative to conventional antibiotics in the treatment of CF-associated bacterial infection.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Risk_factors_studies Idioma: En Revista: Antibiotics (Basel) Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Risk_factors_studies Idioma: En Revista: Antibiotics (Basel) Ano de publicação: 2023 Tipo de documento: Article