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Biomarkers in osteoarthritis: current status and outlook - the FNIH Biomarkers Consortium PROGRESS OA study.
Hunter, David J; Collins, Jamie E; Deveza, Leticia; Hoffmann, Steven C; Kraus, Virginia B.
Afiliação
  • Hunter DJ; Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine, University of Sydney, Australia and Rheumatology Department, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia. David.Hunter@sydney.edu.au.
  • Collins JE; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Deveza L; Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine, University of Sydney, Australia and Rheumatology Department, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia.
  • Hoffmann SC; Foundation for the National Institutes of Health, Bethesda, North, MD, USA.
  • Kraus VB; Duke Molecular Physiology Institute, and Department of Medicine|, Duke University, Durham, NC, USA.
Skeletal Radiol ; 52(11): 2323-2339, 2023 Nov.
Article em En | MEDLINE | ID: mdl-36692532
ABSTRACT
Currently, no disease-modifying therapies are approved for osteoarthritis (OA) use. One obstacle to trial success in this field has been our existing endpoints' limited validity and responsiveness. To overcome this impasse, the Foundation for the NIH OA Biomarkers Consortium is focused on investigating biomarkers for a prognostic context of use for subsequent qualification through regulatory agencies. This narrative review describes this activity and the work underway, focusing on the PROGRESS OA study.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Skeletal Radiol Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Skeletal Radiol Ano de publicação: 2023 Tipo de documento: Article