Stereoselective Synthesis of 2-Deoxy Glycosides via Iron Catalysis.
Org Lett
; 25(5): 832-837, 2023 Feb 10.
Article
em En
| MEDLINE
| ID: mdl-36700622
ABSTRACT
An Fe-catalyzed 2-deoxy glycosylation method was developed from 3,4-O-carbonate glycals directly at room temperature. This novel approach enabled facile access to alkyl and aryl 2-deoxy glycosides in high yields with exclusive α-stereoselectivity, tolerating various alcohols, phenols, and glycals. The synthetic utility and advantage of this strategy have been demonstrated by the modification of six natural products and the construction of a tetrasaccharide.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2023
Tipo de documento:
Article