Tuning metabolic efficiency for increased product yield in high titer fed-batch Chinese hamster ovary cell culture.

Helfer, Apolline; Gros, Sylvain; Kolwyck, Dave; Karst, Daniel J

Helfer, Apolline; Gros, Sylvain; Kolwyck, Dave; Karst, Daniel J.

Afiliação

Helfer A; Process Sciences, Global Manufacturing Sciences, Biogen International GmbH, Luterbach, Switzerland.
Gros S; Process Sciences, Global Manufacturing Sciences, Biogen International GmbH, Luterbach, Switzerland.
Kolwyck D; Process Sciences, Global Manufacturing Sciences, Biogen International GmbH, Luterbach, Switzerland.
Karst DJ; Process Sciences, Global Manufacturing Sciences, Biogen International GmbH, Luterbach, Switzerland.

Biotechnol Prog ; 39(3): e3327, 2023.

Article em En | MEDLINE | ID: mdl-36700684

Assuntos

Amônia; Reatores Biológicos; Cricetinae; Animais; Cricetulus; Células CHO; Amônia/metabolismo; Técnicas de Cultura Celular por Lotes/métodos; Ácido Láctico/metabolismo

Palavras-chave

CHO cell productivity; feed strategy optimization; intensified fed-batch cell culture process; lactate and base feed

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reatores Biológicos / Amônia Limite: Animals Idioma: En Revista: Biotechnol Prog Ano de publicação: 2023 Tipo de documento: Article

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