PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage.

Kim, Chiho; Wang, Xu-Dong; Jang, Seoyeon; Yu, Yonghao

Kim, Chiho; Wang, Xu-Dong; Jang, Seoyeon; Yu, Yonghao.

Afiliação

Kim C; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Wang XD; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Jang S; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Yu Y; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA. Electronic address: yy3213@cumc.columbia.edu.

Biochem Biophys Res Commun ; 646: 78-85, 2023 02 26.

Article em En | MEDLINE | ID: mdl-36706709

Assuntos

Neoplasias; Piroptose; Humanos; Gasderminas; Caspase 3/metabolismo; Poli(ADP-Ribose) Polimerase-1/metabolismo; Morte Celular; Neoplasias/patologia

Palavras-chave

BRCA gene; Caspase 3; Gasdermin E (GSDME); PARP1 inhibitors (PARPi); Poly-ADP-Ribose-polymerase 1 (PARP1); Pyroptosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piroptose / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2023 Tipo de documento: Article

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