Characterization of the structure and control of the blood-nerve barrier identifies avenues for therapeutic delivery.
Dev Cell
; 58(3): 174-191.e8, 2023 02 06.
Article
em En
| MEDLINE
| ID: mdl-36706755
ABSTRACT
The blood barriers of the nervous system protect neural environments but can hinder therapeutic accessibility. The blood-brain barrier (BBB) is well characterized, consisting of endothelial cells with specialized tight junctions and low levels of transcytosis, properties conferred by contacting pericytes and astrocytes. In contrast, the blood-nerve barrier (BNB) of the peripheral nervous system is poorly defined. Here, we characterize the structure of the mammalian BNB, identify the processes that confer barrier function, and demonstrate how the barrier can be opened in response to injury. The homeostatic BNB is leakier than the BBB, which we show is due to higher levels of transcytosis. However, the barrier is reinforced by macrophages that specifically engulf leaked materials, identifying a role for resident macrophages as an important component of the BNB. Finally, we demonstrate the exploitation of these processes to effectively deliver RNA-targeting therapeutics to peripheral nerves, indicating new treatment approaches for nervous system pathologies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Endoteliais
/
Barreira Hematoneural
Aspecto:
Implementation_research
Limite:
Animals
Idioma:
En
Revista:
Dev Cell
Ano de publicação:
2023
Tipo de documento:
Article