Real world use of dolutegravir two drug regimens.
AIDS
; 37(5): 785-788, 2023 04 01.
Article
em En
| MEDLINE
| ID: mdl-36728219
ABSTRACT
BACKGROUND:
Since 2015, we prescribed dolutegravir (DTG)-based two drug regimens (DTG-2DR) for 620 people [total cohort 3133 (19.8%)].METHOD:
Clinic database search 1 January 15 to 31 October 21. Demographic, tolerability and HIV related data analysed.RESULTS:
In total, 620 people identified; 561 had complete data. 446 male (79.5%); median age 54 years (interquartile range 46, 59). 343 (61.1%) MSM. Nine people who initiated naïvely achieved viral suppression (100%). 546/552 (99.0%) switched or continued and were suppressed at data censor. 460/552 (83.3%) received DTG-lamivudine (DTG/3TC), 74/552 (13.4%) received DTG-rilpivirine (DTG/RPV) and 18/552 (3.3%) received DTG-emtricitabine (DTG/FTC). 70 (12.5%) switched off DTG-2DR (55 DTG/3TC, 13 DTG/RPV, two DTG/FTC) due to side-effects. 41 episodes of blip (1 off >50 copies/ml) occurred in 30 people (5.3%). 11/41 on DTG-RPV [ n â=â7 multi-tablet regimen (MTR), n â=â4 single tablet regimen (STR)]. 27/41 DTG-3TC, 3/41 DTG/FTC ( n â=â26 MTR, n â=â4 STR). Six people (1.1%) failed (confirmed viral load >200 copies/ml or persistent low level viraemia) ( n â=â4 DTG-3TC STR, n â=â1 DTG-3TC MTR, n â=â1 DTG-RPV MTR). Four failures due to low level viraemia, one due to non-adherence and one due to high viral load. Resistance tests performed for 5/6 - mutations detected only in latter person with high viral load failure (on DTG-3TC MTR) who developed triple class resistance.CONCLUSION:
Majority of experience is in DTG/3TC stable switch. Minority of patients developed side-effects. Low number of virological failures, one developed integrase inhibitor resistance. Viral failure associated with MTR, commensurate with trial data showing no failure with resistance if DTG/3TC STR used. Overall DTG-2DR demonstrates high efficacy in real-world setting.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Fármacos Anti-HIV
/
Minorias Sexuais e de Gênero
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
AIDS
Ano de publicação:
2023
Tipo de documento:
Article