Some pharmacokinetic data about furaltadone and nitrofurazone administered orally to preruminant calves.
Vet Q
; 9(3): 208-14, 1987 Jul.
Article
em En
| MEDLINE
| ID: mdl-3672857
ABSTRACT
A single oral dosage of furaltadone and nitrofurazone (14.0 mg/kg) to 5 preruminant calves (in a cross-over trial) revealed mean maximum plasma concentration of 2.5 and 3.5 microgram/ml, respectively, at approximately 3 h after administration. The final elimination half-lives of furaltadone and nitrofurazone were 2.5 and 5 h, respectively. Urinary recovery of these two nitrofurans in 3 calves revealed approximately 2% of the orally administered dose. The renal clearance of the unbound drugs did not differ (for both drugs approximately 0.42 ml/min/kg); furaltadone clearance was strongly related to urine flow.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bovinos
/
Oxazolidinonas
/
Anti-Infecciosos Urinários
/
Nitrofuranos
/
Nitrofurazona
Limite:
Animals
Idioma:
En
Revista:
Vet Q
Ano de publicação:
1987
Tipo de documento:
Article