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Escalating spread of SARS-CoV-2 infection after school reopening among students in hotspot districts of Oromia Region in Ethiopia: Longitudinal study.
Gobena, Dabesa; Kebede Gudina, Esayas; Yilma, Daniel; Girma, Tsinuel; Gebre, Getu; Gelanew, Tesfaye; Abdissa, Alemseged; Mulleta, Daba; Sarbessa, Tarekegn; Asefa, Henok; Woldie, Mirkuzie; Shumi, Gemechu; Kenate, Birhanu; Kroidl, Arne; Wieser, Andreas; Eshetu, Beza; Degfie, Tizta Tilahun; Mekonnen, Zeleke.
Afiliação
  • Gobena D; Public Health Emergency Management and Health Research Directorate, Oromia Health Bureau, Addis Ababa, Ethiopia.
  • Kebede Gudina E; School of Medical Laboratory Science, Institute of Health, Jimma University, Jimma, Ethiopia.
  • Yilma D; Department of Internal Medicine, Jimma University, Jimma, Ethiopia.
  • Girma T; Department of Internal Medicine, Jimma University, Jimma, Ethiopia.
  • Gebre G; Fenot Project, School of Population and Public Health, University of British Columbia, Addis Ababa, Ethiopia.
  • Gelanew T; Public Health Emergency Management and Health Research Directorate, Oromia Health Bureau, Addis Ababa, Ethiopia.
  • Abdissa A; Armauer Hanssen Research Institute, Addis Ababa, Ethiopia.
  • Mulleta D; Armauer Hanssen Research Institute, Addis Ababa, Ethiopia.
  • Sarbessa T; Public Health Emergency Management and Health Research Directorate, Oromia Health Bureau, Addis Ababa, Ethiopia.
  • Asefa H; Public Health Emergency Management and Health Research Directorate, Oromia Health Bureau, Addis Ababa, Ethiopia.
  • Woldie M; Department of Epidemiology, Jimma University, Jimma, Ethiopia.
  • Shumi G; Fenot Project, School of Population and Public Health, University of British Columbia, Addis Ababa, Ethiopia.
  • Kenate B; Fenot Project, School of Population and Public Health, University of British Columbia, Addis Ababa, Ethiopia.
  • Kroidl A; Fenot Project, School of Population and Public Health, University of British Columbia, Addis Ababa, Ethiopia.
  • Wieser A; Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Munich, Germany.
  • Eshetu B; German Center for Infection Research, Partner Site Munich, Munich, Germany.
  • Degfie TT; Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Munich, Germany.
  • Mekonnen Z; German Center for Infection Research, Partner Site Munich, Munich, Germany.
PLoS One ; 18(2): e0280801, 2023.
Article em En | MEDLINE | ID: mdl-36735689
ABSTRACT

BACKGROUND:

COVID-19 pandemic caused by extended variants of SARS-CoV-2 has infected more than 350 million people, resulting in over 5.5 million deaths globally. However, the actual burden of the pandemic in Africa, particularly among children, remains largely unknown. We aimed to assess the seroepidemiological changes of SARS-CoV-2 infection after school reopening among school children in Oromia, Ethiopia.

METHODS:

A prospective cohort study involving students aged 10 years and older were used. A serological survey was performed twice, at school reopening in December 2020 and four months later in April 2021. Participants were selected from 60 schools located in 15 COVID-19 hotspot districts in Oromia Region. Serology tests were performed by Elecsys anti-SARS-CoV-2 nucleocapsid assay. Data were collected using CSentry CSProData Entry 7.2.1 and exported to STATA version 14.2 for data cleaning and analysis.

RESULTS:

A total of 1884 students were recruited at baseline, and 1271 completed the follow-up. SARS-CoV-2 seroprevalence almost doubled in four months from 25.7% at baseline to 46.3% in the second round, with a corresponding seroincidence of 1910 per 100,000 person-week. Seroincidence was found to be higher among secondary school students (grade 9-12) compared to primary school students (grade 4-8) (RR = 1.6, 95% CI 1.21-2.22) and among those with large family size (> = 5) than those with a family size of <3 (RR = 2.1, 95% CI 1.09-4.17). The increase in SARS-CoV-2 seroprevalence among the students corresponded with Ethiopia's second wave of the COVID-19 outbreak.

CONCLUSION:

SARS-CoV-2 seroprevalence among students in hotspot districts of the Oromia Region was high even at baseline and almost doubled within four months of school recommencement. The high seroincidence coincided with the second wave of the COVID-19 outbreak in Ethiopia, indicating a possible contribution to school opening for the new outbreak wave.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Child / Humans País/Região como assunto: Africa Idioma: En Revista: PLoS One Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Child / Humans País/Região como assunto: Africa Idioma: En Revista: PLoS One Ano de publicação: 2023 Tipo de documento: Article