Chemogenetic activation of lateral habenula accelerates the extinction of the appetitive conditioned responses.
Behav Neurosci
; 137(2): 95-100, 2023 Apr.
Article
em En
| MEDLINE
| ID: mdl-36757972
ABSTRACT
A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation accelerated the decline in conditioned food-cup responses during extinction. The present results and the reports of previous LHb lesion studies suggest that LHb mediates appetitive extinction. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Habenula
Limite:
Animals
Idioma:
En
Revista:
Behav Neurosci
Ano de publicação:
2023
Tipo de documento:
Article