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Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.
Nguyen, Thu P; Wang, Wentian; Sternisha, Alex C; Corley, Chase D; Wang, Hua-Yu Leo; Wang, Xiaoyu; Ortiz, Francisco; Lim, Sang-Kyun; Abdullah, Kalil G; Parada, Luis F; Williams, Noelle S; McBrayer, Samuel K; McDonald, Jeffrey G; De Brabander, Jef K; Nijhawan, Deepak.
Afiliação
  • Nguyen TP; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wang W; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Sternisha AC; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Corley CD; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wang HL; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wang X; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Ortiz F; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Lim SK; Department of Development Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Abdullah KG; Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Parada LF; Department of Development Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Williams NS; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • McBrayer SK; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • McDonald JG; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • De Brabander JK; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jef.debrabander@utsouthwestern.edu.
  • Nijhawan D; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, Program in Molecular Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: deepak.nijhawan@utsouthwestern.edu.
Cell Chem Biol ; 30(2): 214-229.e18, 2023 02 16.
Article em En | MEDLINE | ID: mdl-36758549
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glioblastoma / Glioma Limite: Adult / Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glioblastoma / Glioma Limite: Adult / Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2023 Tipo de documento: Article