Synthesis and biological evaluation of 2,5-disubstituted furan derivatives containing 1,3-thiazole moiety as potential &#945;-glucosidase inhibitors.

He, Min; Li, Yuan-Jing; Shao, Jiang; Li, Ya-Sheng; Cui, Zi-Ning

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives containing 1,3-thiazole moiety as potential α-glucosidase inhibitors.

He, Min; Li, Yuan-Jing; Shao, Jiang; Li, Ya-Sheng; Cui, Zi-Ning.

Afiliação

He M; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China.
Li YJ; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China.
Shao J; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China.
Li YS; Department of Infectious Diseases & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address: li__ysh@163.com.
Cui ZN; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China. Ele

Bioorg Med Chem Lett ; 83: 129173, 2023 03 01.

Article em En | MEDLINE | ID: mdl-36764471

Assuntos

Diabetes Mellitus Tipo 2; Inibidores de Glicosídeo Hidrolases; Humanos; alfa-Glucosidases/metabolismo; Inibidores de Glicosídeo Hidrolases/farmacologia; Células HEK293; Cinética; Simulação de Acoplamento Molecular; Estrutura Molecular; Relação Estrutura-Atividade; Tiazóis/farmacologia; Furanos/química

Palavras-chave

1,3-Thiazole; 2,5-Disubstituted furan; Molecular docking; Structure-activity relationship; α-Glucosidase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Inibidores de Glicosídeo Hidrolases Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2023 Tipo de documento: Article

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