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Design, synthesis and evaluation of the novel chalcone derivatives with 2,2-dimethylbenzopyran as HIF-1 inhibitors that possess anti-angiogenic potential.
Xu, Huashen; Wang, Jianmin; Chen, Yuanguang; Du, Yang; Chen, Lu; Wu, Chunfu; Wang, Lihui; Chen, Guoliang.
Afiliação
  • Xu H; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Wang J; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, 117004, PR China.
  • Chen Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Du Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Chen L; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
  • Wu C; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, 117004, PR China.
  • Wang L; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, 117004, PR China. Electronic address: wlhcw@163.com.
  • Chen G; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: spucgl@163.com.
Eur J Med Chem ; 250: 115171, 2023 Mar 15.
Article em En | MEDLINE | ID: mdl-36774697
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chalcona / Chalconas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chalcona / Chalconas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article