Enhancing Alkyne-Based Raman Tags with a Sulfur Linker.
J Phys Chem B
; 127(9): 1976-1982, 2023 03 09.
Article
em En
| MEDLINE
| ID: mdl-36821830
Alkyne-based Raman tags have proven their utility for biological imaging. Although the alkynyl stretching mode is a relatively strong Raman scatterer, the detection sensitivity of alkyne-tagged compounds is ultimately limited by the magnitude of the probe's Raman response. In order to improve the performance of alkyne-based Raman probes, we have designed several tags that benefit from π-π conjugation as well as from additional n-π conjugation with a sulfur linker. We show that the sulfur linker provides additional enhancement and line width narrowing, offering a simple yet effective strategy for improving alkyne-based Raman tags. We validate the utility of various sulfur-linked alkyne tags for cellular imaging through stimulated Raman scattering microscopy.
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01-internacional
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MEDLINE
Assunto principal:
Análise Espectral Raman
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Idioma:
En
Revista:
J Phys Chem B
Ano de publicação:
2023
Tipo de documento:
Article