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Evaluation of High Intracranial Plaque Prevalence in Type 2 Diabetes Using Vessel Wall Imaging on 7 T Magnetic Resonance Imaging.
Shozushima, Masaharu; Mori, Futoshi; Yashiro, Satoshi; Todate, Yusuke; Oda, Tomoyasu; Nagasawa, Kan; Hasegawa, Yutaka; Takebe, Noriko; Sasaki, Makoto; Ishigaki, Yasushi.
Afiliação
  • Shozushima M; Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan.
  • Mori F; Division of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba 028-3694, Japan.
  • Yashiro S; Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan.
  • Todate Y; Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan.
  • Oda T; Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan.
  • Nagasawa K; Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan.
  • Hasegawa Y; Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan.
  • Takebe N; Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan.
  • Sasaki M; Division of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba 028-3694, Japan.
  • Ishigaki Y; Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3695, Japan.
Brain Sci ; 13(2)2023 Jan 28.
Article em En | MEDLINE | ID: mdl-36831760
BACKGROUND: While type 2 diabetes (T2D) is a major risk for ischemic stroke, the associated vessel wall characteristics remain essentially unknown. This study aimed to clarify intracranial vascular changes on three-dimensional vessel wall imaging (3D-VWI) using fast spin echo by employing 7Tesla (7T) magnetic resonance imaging (MRI) in T2D patients without advanced atherosclerosis as compared to healthy controls. METHODS: In 48 T2D patients and 35 healthy controls, the prevalence of cerebral small vessel diseases and intracranial plaques were evaluated by 3D-VWI with 7T MRI. RESULTS: The prevalence rate of lacunar infarction was significantly higher in T2D than in controls (n = 8 in T2D vs. n = 0 in control, p = 0.011). The mean number of intracranial plaques in both anterior and posterior circulation of each subject was significantly larger in T2D than in controls (2.23 in T2D vs. 0.94 in control, p < 0.01). In T2D patients, gender was associated with the presence of intracranial plaques. CONCLUSION: This is the first study to demonstrate the high prevalence of intracranial plaque in T2D patients with neither confirmed atherosclerotic disease nor symptoms by performing intracranial 3D-VWI employing 7TMRI. Investigation of intracranial VWI with 7T MRI is expected to provide novel insights allowing early intensive risk management for prevention of ischemic stroke in T2D patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prevalence_studies / Risk_factors_studies Idioma: En Revista: Brain Sci Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prevalence_studies / Risk_factors_studies Idioma: En Revista: Brain Sci Ano de publicação: 2023 Tipo de documento: Article