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Modulation of amygdala activity for emotional faces due to botulinum toxin type A injections that prevent frowning.
Stark, Shauna; Stark, Craig; Wong, Brian; Brin, Mitchell F.
Afiliação
  • Stark S; Department of Neurobiology and Behavior, University of California Irvine, Irvine, USA.
  • Stark C; Department of Neurobiology and Behavior, University of California Irvine, Irvine, USA.
  • Wong B; Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Irvine, USA.
  • Brin MF; Department of Neurology, University of California Irvine, Irvine, USA. Mitchell.Brin@AbbVie.com.
Sci Rep ; 13(1): 3333, 2023 02 27.
Article em En | MEDLINE | ID: mdl-36849797
ABSTRACT
According to the facial feedback hypothesis, when we see an angry or happy face, we contract or flex the relevant muscles to recreate the expression to assist in identifying and experiencing the emotion reflected. We investigated the facial feedback hypothesis by using botulinum toxin type A (onabotulinumtoxinA; onabotA) injections to induce temporary paralysis in the glabellar muscles (responsible for frowning) and measured functional brain activity during the processing of emotional faces. Ten females viewed pictures of happy and angry faces during two functional magnetic resonance imaging (fMRI) scan sessions one prior (Pre) to onabotA and one following (Active) onabotA injections. We found Pre vs. Active onabotA modulation of activity in the amygdala for both happy and angry faces, as well as modulation of activity in the fusiform gyrus for happy faces. Consistent with our predictions, preventing frowning through inhibition of glabellar muscle contraction altered amygdala processing for emotional faces. The modulation of amygdala and fusiform gyrus activity following onabotA may reflect compensatory processes in a neuroanatomical circuit involved in emotional processing that is engaged when facial feedback is impaired. These data contribute to a growing literature suggesting that inhibition of glabellar muscle contraction alters neural activity for emotional processing.Clinical Trials.gov registration number NCT03373162.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxinas Botulínicas Tipo A Limite: Female / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxinas Botulínicas Tipo A Limite: Female / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2023 Tipo de documento: Article