Gonadotropins as pharmacological agents in assisted reproductive technology and polycystic ovary syndrome.
Trends Endocrinol Metab
; 34(4): 194-215, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36863888
ABSTRACT
Polycystic ovary syndrome (PCOS) is a complex endocrinopathy associated with subfertility/infertility and pregnancy complications. Most PCOS women opt for assisted reproductive technologies (ART) for successful conception; however, optimization of the relative doses of the gonadotropins [follicle-stimulating hormone (FSH), luteinizing hormone (LH)/human chorionic gonadotropin (hCG)] for appropriate steroidogenesis, without causing ovarian hyperstimulatory syndrome (OHSS), is challenging. Embryonic factors probably do not contribute to pregnancy loss in PCOS women, albeit hormonal imbalance impairs the metabolic microenvironment critical for oocyte maturation and endometrial receptivity. Certain clinical studies have confirmed the role of metabolic corrections in increasing the rate of pregnancy in PCOS women. This review focuses on the impact of untimely high LHCGR and/or LH levels on oocyte/embryo quality, pregnancy outcomes in ART, and exploring LHCGR as a potential drug target in PCOS women.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Síndrome de Hiperestimulação Ovariana
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Trends Endocrinol Metab
Ano de publicação:
2023
Tipo de documento:
Article