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From multiallele fish to nonstandard environments, how ZFIN assigns phenotypes, human disease models, and gene expression annotations to genes.
Bradford, Yvonne M; Van Slyke, Ceri E; Howe, Douglas G; Fashena, David; Frazer, Ken; Martin, Ryan; Paddock, Holly; Pich, Christian; Ramachandran, Sridhar; Ruzicka, Leyla; Singer, Amy; Taylor, Ryan; Tseng, Wei-Chia; Westerfield, Monte.
Afiliação
  • Bradford YM; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Van Slyke CE; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Howe DG; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Fashena D; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Frazer K; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Martin R; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Paddock H; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Pich C; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Ramachandran S; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Ruzicka L; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Singer A; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Taylor R; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Tseng WC; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Westerfield M; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
Genetics ; 224(1)2023 05 04.
Article em En | MEDLINE | ID: mdl-36864549
ABSTRACT
Danio rerio is a model organism used to investigate vertebrate development. Manipulation of the zebrafish genome and resultant gene products by mutation or targeted knockdown has made the zebrafish a good system for investigating gene function, providing a resource to investigate genetic contributors to phenotype and human disease. Phenotypic outcomes can be the result of gene mutation, targeted knockdown of gene products, manipulation of experimental conditions, or any combination thereof. Zebrafish have been used in various genetic and chemical screens to identify genetic and environmental contributors to phenotype and disease outcomes. The Zebrafish Information Network (ZFIN, zfin.org) is the central repository for genetic, genomic, and phenotypic data that result from research using D. rerio. Here we describe how ZFIN annotates phenotype, expression, and disease model data across various experimental designs, how we computationally determine wild-type gene expression, the phenotypic gene, and how these results allow us to propagate gene expression, phenotype, and disease model data to the correct gene, or gene related entity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Genoma Limite: Animals / Humans Idioma: En Revista: Genetics Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Genoma Limite: Animals / Humans Idioma: En Revista: Genetics Ano de publicação: 2023 Tipo de documento: Article