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Low and differential polygenic score generalizability among African populations due largely to genetic diversity.
Majara, Lerato; Kalungi, Allan; Koen, Nastassja; Tsuo, Kristin; Wang, Ying; Gupta, Rahul; Nkambule, Lethukuthula L; Zar, Heather; Stein, Dan J; Kinyanda, Eugene; Atkinson, Elizabeth G; Martin, Alicia R.
Afiliação
  • Majara L; Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER), Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
  • Kalungi A; MRC Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.
  • Koen N; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
  • Tsuo K; Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER), Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
  • Wang Y; Department of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Gupta R; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Nkambule LL; Mental Health Project, Medical Research Council/Uganda Virus Research Institute (MRC/UVRI) & London School of Hygiene and Tropical Medicine (LSHTM), Uganda Research Unit, Entebbe, Uganda.
  • Zar H; Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER), Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
  • Stein DJ; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
  • Kinyanda E; South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa.
  • Atkinson EG; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Martin AR; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
HGG Adv ; 4(2): 100184, 2023 04 13.
Article em En | MEDLINE | ID: mdl-36873096
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Aspecto: Equity_inequality Limite: Humans País/Região como assunto: Africa Idioma: En Revista: HGG Adv Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Aspecto: Equity_inequality Limite: Humans País/Região como assunto: Africa Idioma: En Revista: HGG Adv Ano de publicação: 2023 Tipo de documento: Article