Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients.
Future Sci OA
; 8(10): FSO825, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-36874368
ABSTRACT
Aim:
The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis.Methods:
Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA.Results:
Angiopoietin-2 levels elevated according to the severity of sepsis progression. Angiopoietin-2 levels were correlated with mean arterial pressure and platelets counts, total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778).Conclusion:
Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.
The study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis in plasma from 105 patients with severe sepsis by ELISA. The results showed that angiopoietin-2 levels elevated according to the severity of sepsis progression and were correlated with important clinical parameters such as mean arterial pressure and platelets counts, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis and septic shock. Thus, plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Future Sci OA
Ano de publicação:
2022
Tipo de documento:
Article