Your browser doesn't support javascript.
loading
Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide.
Ceña-Diez, Rafael; Spetz, Anna-Lena; Sönnerborg, Anders.
Afiliação
  • Ceña-Diez R; Division of Infectious Diseases/ANA Futura, Department of Medicine Huddinge, Karolinska Institutet, Alfred Nobels Allé 8, 141 52 Huddinge, Sweden. Electronic address: rafael.cena.diez@ki.se.
  • Spetz AL; Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden.
  • Sönnerborg A; Division of Infectious Diseases/ANA Futura, Department of Medicine Huddinge, Karolinska Institutet, Alfred Nobels Allé 8, 141 52 Huddinge, Sweden; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Drug Resist Updat ; 68: 100955, 2023 05.
Article em En | MEDLINE | ID: mdl-36878096
ABSTRACT
The novel dipeptide WG-am and single-stranded oligonucleotide combination (WG-amssON) showed synergistic antiviral activity against HIV-1 integrase-, protease- or reverse transcriptase drug resistant isolates, with over 95% reduction. The highest selectivity indexes were for integrase resistant isolates. WG-amssON can be a future option for treatment of HIV drug-resistant strains.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: HIV-1 / Inibidores de Integrase de HIV Limite: Humans Idioma: En Revista: Drug Resist Updat Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: HIV-1 / Inibidores de Integrase de HIV Limite: Humans Idioma: En Revista: Drug Resist Updat Ano de publicação: 2023 Tipo de documento: Article