Contributions of 3D chromatin structure to cell-type-specific gene regulation.
Curr Opin Genet Dev
; 79: 102032, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36893484
ABSTRACT
Eukaryotic genomes are organized in 3D in a multiscale manner, and different mechanisms acting at each of these scales can contribute to transcriptional regulation. However, the large single-cell variability in 3D chromatin structures represents a challenge to understand how transcription may be differentially regulated between cell types in a robust and efficient manner. Here, we describe the different mechanisms by which 3D chromatin structure was shown to contribute to cell-type-specific transcriptional regulation. Excitingly, several novel methodologies able to measure 3D chromatin conformation and transcription in single cells in their native tissue context, or to detect the dynamics of cis-regulatory interactions, are starting to allow quantitative dissection of chromatin structure noise and relate it to how transcription may be regulated between different cell types and cell states.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Regulação da Expressão Gênica
Idioma:
En
Revista:
Curr Opin Genet Dev
Ano de publicação:
2023
Tipo de documento:
Article