Hepatoprotective potential of gabapentin in cecal ligation and puncture-induced sepsis; targeting oxidative stress, apoptosis, and NF-kB/MAPK signaling pathways.

Abdelnaser, Mahmoud; Alaaeldin, Rania; Attya, Mina Ezzat; Fathy, Moustafa

Abdelnaser, Mahmoud; Alaaeldin, Rania; Attya, Mina Ezzat; Fathy, Moustafa.

Afiliação

Abdelnaser M; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: mahmoud.abdelnaser@deraya.edu.eg.
Alaaeldin R; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: rania.alaadin@deraya.edu.eg.
Attya ME; Department of Pathology, Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: mena.ezzat@mu.edu.eg.
Fathy M; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Electronic address: mostafa_fathe@mu.edu.eg.

Life Sci ; 320: 121562, 2023 May 01.

Article em En | MEDLINE | ID: mdl-36907325

Assuntos

NF-kappa B; Sepse; Ratos; Masculino; Animais; NF-kappa B/metabolismo; Caspase 3/metabolismo; Gabapentina/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Sistema de Sinalização das MAP Quinases; Interleucina-6/metabolismo; Proteína X Associada a bcl-2/metabolismo; Ratos Wistar; Transdução de Sinais; Estresse Oxidativo; Punções; Sepse/complicações; Sepse/tratamento farmacológico; Sepse/genética; Apoptose

Palavras-chave

Apoptosis; CLP; Cleaved caspase 3; Gabapentin; MAPK; NF-kB; TNF-α

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Sepse Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2023 Tipo de documento: Article

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