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Transfer and toxicokinetic modeling of non-dioxin-like polychlorinated biphenyls (ndl-PCBs) into accidentally exposed dairy cattle and their calves - A case report.
Moenning, Jan-Louis; Numata, Jorge; Bloch, Dorit; Jahnke, Anne; Schafft, Helmut A; Spolders, Markus; Lüth, Anja; Lahrssen-Wiederholt, Monika; Schulz, Kirsten.
Afiliação
  • Moenning JL; German Federal Institute for Risk Assessment, Berlin, Germany.
  • Numata J; German Federal Institute for Risk Assessment, Berlin, Germany.
  • Bloch D; German Federal Institute for Risk Assessment, Berlin, Germany.
  • Jahnke A; German Federal Institute for Risk Assessment, Berlin, Germany.
  • Schafft HA; German Federal Institute for Risk Assessment, Berlin, Germany.
  • Spolders M; German Federal Institute for Risk Assessment, Berlin, Germany.
  • Lüth A; German Federal Institute for Risk Assessment, Berlin, Germany.
  • Lahrssen-Wiederholt M; German Federal Institute for Risk Assessment, Berlin, Germany.
  • Schulz K; German Federal Institute for Risk Assessment, Berlin, Germany. Electronic address: kirsten.schulz@bfr.bund.de.
Environ Toxicol Pharmacol ; 99: 104106, 2023 Apr.
Article em En | MEDLINE | ID: mdl-36907369
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that accumulate in tissues of exposed animals and humans. This case report refers ton=3 dairy cows accidentally exposed to non-dioxin-like PCBs (ndl-PCBs) of unknown origin on a German farm. At study start they had a cumulative total of 122-643 ng/g fat in milk and 105-591 ng/g fat in blood, consisting mainly of PCBs 138, 153, and 180. Two cows calved during the study and their calves were raised on their mothers' milk, resulting in cumulative exposure until slaughter. A physiologically based toxicokinetic model was developed to describe the fate of ndl-PCBs in the animals. The toxicokinetic behavior of ndl-PCBs was simulated in individual animals, including transfer of contaminants into calves via milk and placenta. Both the simulations and experimental data indicate that contamination via both routes is significant. In addition, the model was used to estimate kinetic parameters for risk assessment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofuranos / Bifenilos Policlorados / Poluentes Ambientais Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Environ Toxicol Pharmacol Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofuranos / Bifenilos Policlorados / Poluentes Ambientais Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Environ Toxicol Pharmacol Ano de publicação: 2023 Tipo de documento: Article