Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates.

Uffelmann, Emil; Posthuma, Danielle; Peyrot, Wouter J

Uffelmann, Emil; Posthuma, Danielle; Peyrot, Wouter J.

Afiliação

Uffelmann E; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands. e.uffelmann@vu.nl.
Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands.
Peyrot WJ; Department of Child and Adolescent Psychiatry and Pediatric Psychology, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Sci Rep ; 13(1): 4219, 2023 03 14.

Article em En | MEDLINE | ID: mdl-36918594

Assuntos

Doença de Alzheimer; Estudo de Associação Genômica Ampla; Humanos; Bancos de Espécimes Biológicos; Fenótipo; Fatores de Risco; Reino Unido

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estudo de Associação Genômica Ampla / Doença de Alzheimer Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Sci Rep Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google