Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion.

Huang, Xiaoyan; Guo, Mingyan; Zhang, Yangfan; Xie, Jiatian; Huang, Rong; Zuo, Zhiyi; Saw, Phei Er; Cao, Minghui

Huang, Xiaoyan; Guo, Mingyan; Zhang, Yangfan; Xie, Jiatian; Huang, Rong; Zuo, Zhiyi; Saw, Phei Er; Cao, Minghui.

Afiliação

Huang X; Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Guo M; Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Zhang Y; Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Xie J; Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Huang R; Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Zuo Z; Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, USA.
Saw PE; Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Cao M; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Glia ; 71(7): 1607-1625, 2023 07.

Article em En | MEDLINE | ID: mdl-36929654

Assuntos

Lesões Encefálicas; Isquemia Encefálica; AVC Isquêmico; Acidente Vascular Cerebral; Camundongos; Animais; Proteína Antagonista do Receptor de Interleucina 1/metabolismo; Proteína Antagonista do Receptor de Interleucina 1/farmacologia; AVC Isquêmico/metabolismo; Quimiocina CXCL1/metabolismo; Quimiocina CXCL1/farmacologia; Microglia/metabolismo; Infiltração de Neutrófilos/fisiologia; Lesões Encefálicas/metabolismo; Camundongos Transgênicos; Isquemia Encefálica/metabolismo; Acidente Vascular Cerebral/metabolismo

Palavras-chave

CXCL1; IL-1RA; ischemic stroke; microglia; neutrophils

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Isquemia Encefálica / Acidente Vascular Cerebral / AVC Isquêmico Limite: Animals Idioma: En Revista: Glia Ano de publicação: 2023 Tipo de documento: Article

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