Sensing, signalling, and regulatory mechanism of cold-stress tolerance in plants.

ABSTRACT

Cold stress is a crucial environmental factor influencing growth and distribution and possessing yield penalties. To survive in the cold, plants have evolved to use a range of molecular mechanisms. The major regulatory pathway under low-temperature stress involves the conversion of external stimulus into an internal signal that triggers a defence mechanism through a transcriptional cascade to counter stress. Cold-receptive mechanism and cell signalling involve cold-related signalling molecules, sensors, calcium signals, MAPK cascade, and ICE-COR-CBF pathway that modulate signal transduction in plants. Of these, the ICE-CBF-COR signalling is considered to be an important regulator for cold-stress acclimation. ICE stimulates acclimation to cold and plays a pivotal role in regulating CBF-mediated cold-tolerance mechanism. Thus, CBFs regulate COR gene expression by binding to its promoter. Similarly, the C-repeat binding factor-dependent signalling cascade also stimulates osmotic stress-regulatory gene expression. This review elucidates the regulatory mechanism underlying cold stress, i.e., signal molecules, cold receptors, signal-transduction pathways, metabolic regulation under cold stress, and crosstalk of regulatory pathways with other abiotic stresses in plants. The results may pave the way for crop improvement in low-temperature environments.