Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs.

Qi, Ran; Bai, Yixuan; Li, Kun; Liu, Nanbin; Xu, Yan; Dal, Emre; Wang, Yufeng; Lin, Rui; Wang, Hui; Liu, Zhongyan; Li, Xinbo; Wang, Xiuyan; Shi, Baomin

Qi, Ran; Bai, Yixuan; Li, Kun; Liu, Nanbin; Xu, Yan; Dal, Emre; Wang, Yufeng; Lin, Rui; Wang, Hui; Liu, Zhongyan; Li, Xinbo; Wang, Xiuyan; Shi, Baomin.

Afiliação

Qi R; Department of general surgery, Tongji Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Bai Y; Department of digestive medicine, Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian, Liaoning, China.
Li K; Department of general surgery, Tongji Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Liu N; Department of general surgery, Tongji Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Xu Y; Department of general surgery, Tongji Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Dal E; University of Utah, Salt Lake City, UT, USA.
Wang Y; Department of general surgery, Tongji Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Lin R; Department of general surgery, Tongji Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Wang H; Department of general surgery, Tongji Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Liu Z; Department of general surgery, Tongji Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Li X; ICON Speciality Labs, Portland, OR, USA.
Wang X; Department of Ultrasonography, Tongji Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China. Electronic address: tjwangxiuyan@tongji.edu.cn.
Shi B; Department of general surgery, Tongji Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China; Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Electronic address: tjshibaomin@tongji.e

Drug Resist Updat ; 68: 100960, 2023 05.

Article em En | MEDLINE | ID: mdl-37003125

Assuntos

Fibroblastos Associados a Câncer; Carcinoma Ductal Pancreático; Exossomos; Ferroptose; MicroRNAs; Neoplasias Pancreáticas; Humanos; Animais; Camundongos; Gencitabina; MicroRNAs/genética; MicroRNAs/metabolismo; Exossomos/genética; Exossomos/patologia; Ferroptose/genética; Fibroblastos Associados a Câncer/metabolismo; Desoxicitidina/farmacologia; Desoxicitidina/uso terapêutico; Desoxicitidina/metabolismo; Resistencia a Medicamentos Antineoplásicos/genética; Linhagem Celular Tumoral; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/genética; Carcinoma Ductal Pancreático/tratamento farmacológico; Carcinoma Ductal Pancreático/genética; Modelos Animais de Doenças; Proliferação de Células; Coenzima A Ligases/metabolismo; Neoplasias Pancreáticas

Palavras-chave

Cancer-associated fibroblasts; Exosomes; Ferroptosis; Pancreatic ductal adenocarcinoma; miR-3173-5p

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / MicroRNAs / Exossomos / Fibroblastos Associados a Câncer / Ferroptose Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Drug Resist Updat Ano de publicação: 2023 Tipo de documento: Article

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