Severe nephrotic syndrome and early end-stage diabetic kidney disease in ABCC8-MODY12: A case report.
Front Genet
; 14: 1132772, 2023.
Article
em En
| MEDLINE
| ID: mdl-37007940
ABSTRACT
A 24-year-old man with diabetes mellitus presented with advanced kidney disease and severe proteinuria. Genetic testing revealed ABCC8-MODY12 (OMIM 600509), and a kidney biopsy showed nodular glomerulosclerosis. He commenced dialysis shortly thereafter, and glycemic control improved on treatment with a sulfonylurea. Diabetic end-stage kidney disease in patients with ABCC8-MODY12 has not been reported until now. Thus, our case highlights the risk for early-onset and severe diabetic kidney disease in patients with ABCC8-MODY12 and the importance of timely genetic diagnosis in unusual cases of diabetes to allow for proper treatment and prevention of late sequelae of diabetes.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Idioma:
En
Revista:
Front Genet
Ano de publicação:
2023
Tipo de documento:
Article