Role of dysfunctional peri-organ adipose tissue in metabolic disease.
Biochimie
; 212: 12-20, 2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-37019205
ABSTRACT
Metabolic disease is a complex disorder defined by a group with interrelated factors. There is growing evidence that obesity can lead to a variety of metabolic diseases, including diabetes and cardiovascular disease. Excessive adipose tissue (AT) deposition and ectopic accumulation can lead to increased peri-organ AT thickness. Dysregulation of peri-organ (perivascular, perirenal, and epicardial) AT is strongly associated with metabolic disease and its complications. The mechanisms include secretion of cytokines, activation of immunocytes, infiltration of inflammatory cells, involvement of stromal cells, and abnormal miRNA expression. This review discusses the associations and mechanisms by which various types of peri-organ AT affect metabolic diseases while addressing it as a potential future treatment strategy.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Doenças Metabólicas
Limite:
Humans
Idioma:
En
Revista:
Biochimie
Ano de publicação:
2023
Tipo de documento:
Article