Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice.
Genome Biol
; 24(1): 67, 2023 04 06.
Article
em En
| MEDLINE
| ID: mdl-37024923
ABSTRACT
N6-methyladenosine (m6A) modification has been shown to regulate RNA metabolism. Here, we investigate m6A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m6A can be maternally inherited or de novo gained after fertilization. Interestingly, m6A modification on maternal mRNAs not only correlates with mRNA degradation, but also maintains the stability of a small group of mRNAs thereby promoting their translation after fertilization. We identify Ythdc1 and Ythdf2 as key m6A readers for mouse preimplantation development. Our study reveals a key role of m6A mediated RNA metabolism during MZT in mammals.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leitura
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Zigoto
Limite:
Animals
Idioma:
En
Revista:
Genome Biol
Ano de publicação:
2023
Tipo de documento:
Article