FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer.

Xu, Chunjie; Gu, Lei; Hu, Lipeng; Jiang, Chunhui; Li, Qing; Sun, Longci; Zhou, Hong; Liu, Ye; Xue, Hanbing; Li, Jun; Zhang, Zhigang; Zhang, Xueli; Xu, Qing

Xu, Chunjie; Gu, Lei; Hu, Lipeng; Jiang, Chunhui; Li, Qing; Sun, Longci; Zhou, Hong; Liu, Ye; Xue, Hanbing; Li, Jun; Zhang, Zhigang; Zhang, Xueli; Xu, Qing.

Afiliação

Xu C; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Gu L; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Hu L; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China.
Jiang C; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Li Q; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China.
Sun L; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhou H; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Liu Y; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xue H; Division of Gastroenterology and Hepatology; Key Laboratory of Gastroenterology and Hepatology, Ministry of Health; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. medxue@126.com.
Li J; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China. junli@shsci.org.
Zhang Z; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China. zzhang@shsci.org.
Zhang X; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China. xlzhang@shsci.org.
Xu Q; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. renjixuqing@163.com.

Nat Commun ; 14(1): 2042, 2023 04 11.

Article em En | MEDLINE | ID: mdl-37041160

Assuntos

Ácido Araquidônico; Carcinogênese; Neoplasias Colorretais; Ácidos Graxos Dessaturases; Microbioma Gastrointestinal; Bactérias Gram-Negativas; Animais; Camundongos; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/microbiologia; Ácido Araquidônico/metabolismo; Ácidos Graxos Dessaturases/genética; Ácidos Graxos Dessaturases/metabolismo; Células HCT116; Xenoenxertos; Humanos; Proteína da Polipose Adenomatosa do Colo/genética; Camundongos Mutantes; Camundongos Endogâmicos C57BL; Bactérias Gram-Negativas/metabolismo; Carcinogênese/genética; Carcinogênese/metabolismo; Dinoprostona/metabolismo; Camundongos Endogâmicos BALB C

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Ácido Araquidônico / Ácidos Graxos Dessaturases / Carcinogênese / Microbioma Gastrointestinal / Bactérias Gram-Negativas Limite: Animals / Humans Idioma: En Revista: Nat Commun Ano de publicação: 2023 Tipo de documento: Article

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